Kidney disease, moderate—Use with caution. DESCRIPTION. The effect may be increased because of slower removal of the medicine from the body. Share cases and questions with Physicians on Medscape consult. Potassium . OTHER NAME(S): Potassium PHOSPHATES VialPotassium Phosphate M-/D-Basic Syringe Call your doctor for medical advice about side effects. • Use SODIUM phosphate for patients with serum potassium > 4.5 mEq/L and serum sodium < 145mEq/L In addition to inspection of solution; infusion set and catheter should also periodically be checked for precipitates, Therapy may increase risk of hyperkalemia, including life-threatening cardiac events, especially when administered in excessive doses, undiluted or by rapid intravenous infusion, Patients with severe renal impairment and end stage renal disease are at increased risk of developing life-threatening hyperkalemia when administered intravenous potassium, Other patients at increased risk of hyperkalemia include those with severe adrenal insufficiency or treated concurrently with other drugs that cause or increase risk of hyperkalemia; patients with cardiac disease may be more susceptible to effects of hyperkalemia, Consider amount of potassium from all sources when determining dose of drug and do not exceed maximum age-appropriate recommended daily amount of potassium; in patients with moderate renal impairment (eGFR ≥30 mL/min/1.73 m, When administering in intravenous fluids to correct hypophosphatemia, check serum potassium concentration prior to administration; if potassium concentration is 4 mEq/dL or more, do not administer drug and use alternative source of phosphate, Maximum initial or single dose in intravenous fluids to correct hypophosphatemia is phosphorus 45 mmol (potassium 71 mEq); recommended infusion rate of potassium is 10 mEq/hour; continuous electrocardiographic (ECG) monitoring is recommended for higher infusion rates of potassium, Hyperphosphatemia can occur with intravenous administration of potassium phosphates, especially in patients with renal impairment; hyperphosphatemia can cause formation of insoluble calcium phosphorus products with consequent hypocalcemia, neurological irritability with tetany, nephrocalcinosis with acute kidney injury and more rarely, cardiac irritability with arrhythmias, Obtain serum calcium concentrations prior to administration and normalize calcium before administering therapy; monitor serum phosphorus and calcium concentrations during treatment, This product contains aluminum that may be toxic; aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired; premature neonates are at particular risk because of immature kidneys, Preterm infants are at risk for aluminum toxicity because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which also contain aluminum, Patients with renal impairment, including preterm infants, who receive greater than 4 - 5 mcg/kg/day of parenteral aluminum can accumulate aluminum to levels associated with central nervous system and bone toxicity; tissue loading may occur at even lower rates of administration, Exposure to aluminum from therapy is not more than 4.9 mcg/kg/day when adults weighing at least 45 kg are administered recommended maximum dosage of phosphorus (45 mmol/day) for parenteral nutrition or pediatric patients 12 years of age and older weighing at least 40 kg are administered recommended maximum dosage of phosphorus (40 mmol/day) for parenteral nutrition, When prescribing therapy for use in parenteral nutrition solutions containing other small volume parenteral products, total daily patient exposure to aluminum from admixture should be considered and maintained at no more than 5 mcg/kg/day, When used for parenteral nutrition not recommended in adults weighing <45 kg or pediatric patients <12 years of age or weighing <40 kg due to risks of aluminum toxicity, Pediatric patients 12 years of age and older weighing at least 40 kg are administered recommended maximum dosage of phosphorus (40 mmol/day) for parenteral nutrition, Tissue accumulation may occur at even lower doses, Drug must be diluted and administered in intravenous fluids or used as an admixture in parenteral nutrition; not for direct intravenous infusion; infusion of hypertonic solutions into a peripheral vein may result in vein irritation, vein damage, and/or thrombosis, The primary complication of peripheral administration is venous thrombophlebitis, which manifests as pain, erythema, tenderness or a palpable cord; remove catheter as soon as possible and initiate appropriate medical treatment if thrombophlebitis develops, When administered peripherally in intravenous fluids to correct hypophosphatemia, a generally recommended maximum concentration is phosphorus 6.4 mmol/100 mL (potassium 10 mEq/100 mL), Parenteral nutrition solutions with an osmolarity of 900 mOsm/L or greater must be infused through a central catheter, Acyclovir, amiodarone, amphotericin B lipid complex (Abelcet), amphotericin B liposome (AmBisome), anidulafungin, caspofungin, ciprofloxacin, daunorubicin liposome, doripenem, doxacurium, doxorubicin, epirubicin, gemtuzumab ozogamicin, idarubicin, ifosfamide, ketamine, lansoprazole, leucovorin calcium, lorazepam, mitoxantrone, mycophenolate, pantoprazole, quinupristin/dalfopristin, rocuronium, D10% in 0.9% NaCl; D2.5% in Half-strength LR; D5% in LR; Dextrose 5% in Ringer's; Lactated Ringer's; Ringer's injection, Alemtuzumab, aminocaproic acid, argatroban, atenolol, bivalirudin, bleomycin, carboplatin, carmustine, cisplatin, cyclophosphamide, cytarabine, dactinomycin, daptomycin, dexmedetomidine, dexrazoxane, diltiazem, Magnesium sulfate, metoclopramide, verapamil, Dextran 70 6% in D5W; dextran 70 6% in 0.5% NaCl; D10W; D2.5W; D2.5/0.45% NaCl; D5/0.2% NaCl; D5/0.45% NaCl; D5/NS; 0.9% NaCl (NS); 0.45% NaCl; sodium lactate 1/6 M. 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