acne; a skin condition on the cheeks and nose with a reddish rash and acne called acne rosacea Clindamycin has the potential to cause adverse effects on the breast-fed infant's gastrointestinal flora. ACANYA (clindamycin phosphate and benzoyl peroxide) Gel, 1.2%/2.5% is a combination product with two active ingredients in a white to off-white, opaque, smooth, aqueous gel formulation intended for topical use. Brand name: Cleocin. Clindac A 1% is manufactured by the pharma giant Galderma. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Clindamycin Phosphate Topical Gel, 1%, a topical antibiotic, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram in a gel vehicle consisting of carbomer 941, methylparaben, polyethylene glycol 400, propylene glycol, purified water, and sodium hydroxide. This medication may be harmful if swallowed. Following multiple topical applications of clindamycin phosphate at a concentration equivalent to 10 mg clindamycin per mL in an isopropyl alcohol and water solution, very low levels of clindamycin are present in the serum (0 to 3 ng/mL) and less than 0.2% of the dose is recovered in urine as clindamycin. Avoid contact with eyes, and inside the nose, mouth, and all mucous membranes, as this product may be irritating. Clindamycin inhibits bacterial protein synthesis by binding to the 23S RNA of the 50S subunit of the ribosome. Benzoyl peroxide and clindamycin topical may also be used for purposes not listed in this medication guide. The structural formula is represented below: The chemical name for clindamycin phosphate is Methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-α-D-galacto-octopyranoside 2-(dihydrogen phosphate). What Are the Symptoms of Mantle Cell Lymphoma? If used during lactation and clindamycin phosphate gel is applied to the chest, care should be taken to avoid accidental ingestion by the infant. Clean and dry the affected area first. All rights reserved. Itching may be a sign of an allergic reaction to clindamycin. List Clindamycin Phosphate Gel side effects by likelihood and severity. As one of the most powerful antibiotics, both forms are used to treat a wide range of bacterial infections. Dosage Form: gel. Do not use anti-diarrhea or opioid medications if you have the following symptoms because these products may make them worse. Follow all directions on the product package, or use as directed by your doctor. According to the NIH, clindamycin, when prescribed for acne, may be taken orally or applied topically as a cream, phosphate gel, lotion, pad or foam. The foam and one brand of the gel (Clindagel ®) are usually applied once a day. Use enough to cover the entire affected area. Clindamycin phosphate is a water-soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent … If you miss a dose, apply it as soon as you remember. Clinical studies for clindamycin phosphate gel did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. US residents can call their local poison control center at 1-800-222-1222. Dist. This condition may occur while receiving treatment or even weeks to months after treatment has stopped. If you are using the foam, apply it once daily to the affected areas. It works by lowering the microcomedone formation, treating the acne and keratosis pilaris. Clindamycin Phosphate Gel contains Clindamycin Phosphate as an active ingredient. Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Properly discard this product when it is expired or no longer needed. Clindamycin phosphate gel USP, 1% contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)- chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin. The usual adult dosage is 500 milligrams to 2 grams of vancomycin orally per day in three to four divided doses administered for 7 to 10 days. Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. An approximately pea sized amount of the study drug is to be topically administered once daily in the evening for 12 weeks. 0. Studies indicate a toxin(s) produced by clostridia is one primary cause of antibiotic-associated colitis. Available for Android and iOS devices. Check the product package for instructions on how to store your product, or ask your pharmacist. What Conditions does Clindamycin Phosphate Gel Treat? Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Clindagel (clindamycin phosphate gel) topical gel, 1% is a topical antibiotic indicated for topical application in the treatment of acne vulgaris.Common side effects of Clindagel include: skin redness, dry skin, skin peeling, itching, skin sensitivity to sunlight, rash, hair bumps, ; skin irritation, However, orally and parenterally administered clindamycin has been reported to appear in breast milk. Inform your doctor if your condition does not improve or worsens. This is not a complete list of possible side effects. There are no adequate studies in pregnant women during the first trimester of pregnancy. Dr. Ed Friedlander answered. ZIANA (clindamycin phosphate 1.2% and tretinoin 0.025%) Gel, is an antibiotic and retinoid combination gel product with two active ingredients. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. What conditions does Clindamycin Phosphate Gel treat? Monitor the breast-fed infant for possible adverse effects on the gastrointestinal flora, such as diarrhea, candidiasis (thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis. Should you take probiotics with antibiotics. Clindamycin Phosphate Gel works by preventing the growth of bacteria. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. It may take between 2-6 weeks to notice an improvement in your condition, and up to 12 weeks to see the full benefit. The colitis is usually characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus. Therefore, it should be used with caution in patients receiving such agents. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. How long have you been taking Clindamycin Phosphate Gel? A small amount of this medication may be absorbed into your bloodstream and may rarely cause a severe intestinal condition (Clostridium difficile-associated diarrhea) due to a resistant bacteria. Antibiotics & Drinking Alcohol - Is it Safe? Clindamycin/benzoyl peroxide is used topically (applied to the skin) for the treatment of pimples ().Both agents are active against Propionibacterium acnes, a bacterium which has been associated with acne. Clindamycin phosphate gel USP, 1% contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Orally and parenterally administered clindamycin has been associated with severe colitis which may result in patient death. COMMON BRAND NAME (S): Cleocin T, ClindaMax Select one or more newsletters to continue. It is for external use only. Clindamycin phosphate topical solution is available in generic form. by: Taro Pharmaceuticals Inc., Brampton, Ontario, Canada L6T 1C1 Revised: August 2020, Clindamycin Phosphate If the can seems warm or the foam seems runny, run the can under cold water. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Clindamycin phosphate is a water soluble ester of the semi-synthetic antibiotic produced by a 7(S)-chloro-substitution of the 7(R)-hydroxyl group of the parent antibiotic lincomycin. Talk to your pharmacist for more details. FOR TOPICAL USE ONLY. If you notice other effects not listed above, contact your doctor or pharmacist. USP, 1%* It is a clindamycin phosphate gel, a topical solution used for the treatment of acne vulgaris, a long-term skin condition characterized by symptoms such as pimples, blackheads, whiteheads, etc. Vancomycin has been found to be effective in the treatment of antibiotic-associated pseudomembranous colitis produced by, Cholestyramine or colestipol resins bind vancomycin, We comply with the HONcode standard for trustworthy health information -. Large bowel endoscopy should be considered to establish a definitive diagnosis in cases of severe diarrhea. Topical clindamycin will not cure your acne. Apply a thin film of clindamycin phosphate gel USP, 1% twice daily to affected area. receive the generic clindamycin phosphate; tretinoin gel, 1.2%; 0.025%, the reference product or placebo. Because the binding sites for these antibacterial drugs overlap, cross-resistance is sometimes observed among lincosamides, macrolides and streptogramin B. Macrolide-inducible resistance to clindamycin occurs in some isolates of macrolide-resistant bacteria. Clindamycin Phosphate Gel is used for Acne, Acne vulgaris and other conditions. Acne: This often keeps moderately severe acne under control. Clindamycin Phosphate Gel contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. Clindamycin should be used during the first trimester of pregnancy only if clearly needed. Clostridium difficile associated diarrhea (CDAD) has been stated with use of almost all antibacterial brokers, including Cleocin HCl and also might vary in extent from mild looseness of the bowels to deadly colitis. Cholestyramine or colestipol resins bind vancomycin in vitro. This combination medication is used to treat a certain type of acne (inflammatory acne vulgaris). It helps decrease the number and severity of acne pimples and helps pimples that do develop to heal more quickly. 3 thanks. Call your doctor for medical advice about side effects. Clindamycin phosphate gel should be prescribed with caution in atopic individuals. Clindamycin phosphate gel is contraindicated in individuals with a history of hypersensitivity to preparations containing clindamycin or lincomycin, a history of regional enteritis or ulcerative colitis, or a history of antibiotic-associated colitis. Depending on the size of the area to be treated, more than one pad or swab may be necessary. Do not spray the foam directly onto your hands or face, because the foam will begin to melt on contact with warm skin. Talk with the doctor. Clindamycin/benzoyl peroxide is a combination of an antibiotic, clindamycin, and benzoyl peroxide, another drug that has antibacterial effects. In view of the potential for diarrhea, bloody diarrhea and pseudomembranous colitis, the physician should consider whether other agents are more appropriate (see CONTRAINDICATIONS, WARNINGS and ADVERSE REACTIONS). CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Please read the patient information leaflet available from your pharmacist for specific instructions on how to use the foam, and ask about any information that is unclear. Clindamycin … Clindamycin Phosphate Topical Solution for Acne. Clindamycin is active in vitro against most isolates of Propionibacterium acnes; however, the clinical significance is unknown. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding. A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Selected from data included with permission and copyrighted by First Databank, Inc. Uses of Clindamycin Gel and Lotion: It is used to treat pimples (acne). Clindamycin phosphate gel USP, 1% contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram. This drug belongs tothe class of antibiotics known as lincosamides. Topical clindamycin comes as a foam, a gel, a solution (liquid), a lotion, and a pledget (swab) to apply to the skin. Clindamycin and Benzoyl Peroxide Gel, 1%/5% is to be used as directed by the physician. Clindamycin is an antibiotic which works by stopping the growth of bacteria. Storage instructions vary depending on the product. The gel works by inhibiting the formation of new bacteria on the skin. Clindagel® (clindamycin phosphate gel) topical gel, 1%, a topical antibiotic, contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per gram in a gel vehicle consisting of carbomer 941, methylparaben, polyethylene glycol 400, propylene glycol, sodium hydroxide, and purified water. What is Clindamycin Phosphate Gel? Otherwise, call a poison control center right away. It is typically applied to the infected skin area as a gel or a lotion. Canada residents can call a provincial poison control center. It has Adapalene Microspheres plus clindamycin phosphate gel as key ingredients that helps to treat several skin ailments. Last updated on Nov 1, 2020. Clindamycin Phosphate Topical Solution, USP 1% contains clindamycin phosphate, USP, at a concentration equivalent to 10 mg clindamycin per milliliter. This document does not contain all possible drug interactions. Tell your doctor right away if you develop persistent diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool. Clindamycin Phosphate Gel may also be used for purposes not listed in this medication guide. Cases of diarrhea, bloody diarrhea and colitis (including pseudomembranous colitis) have been reported as adverse reactions in patients treated with oral and parenteral formulations of clindamycin and rarely with topical clindamycin (see WARNINGS). However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. Safety and effectiveness in pediatric patients under the age of 12 have not been established. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. 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