The systemic toxicity of dipropylene glycol monomethyl ether is characterized by central nervous system (CNS) depression [1]. 25498-49-1 & 20324-33-8 Propylene glycol methyl ether (PM) CAS No. (C88031) OECD SIDS DIPROPYLENE GLYCOL METHYL ETHER UNEP PUBLICAIONS 1 FOREWORD INTRODUCTION DIPROPYLENE GLYCOL METHYL ETHER CAS N°: 34590-94-8 (Isomers: 13429-07-7, 20324 -32-7; 13588-28-8; and 5 5956-21-3) OECD SIDS DIPROPYLENE GLYCOL METHYL ETHER 2 UNEP PUBLICAIONS SIDS Initial Assessment Report for 12th SIAM (Paris, France, 27-29 June 2001) Chemical Name: DIPROPYLENE GLYCOL … Identification Product form : Substance Trade name : DIPROPYLENE GLYCOL CAS-No. 77, No. 6.1.2 Acute Toxicity ... Dipropylene glycol is a colorless, nearly odorless, and slightly viscous liquid with a high boiling point. (A31713) The systemic toxicity of the ethylene-based glycol ethers is mediated by their metabolism to the corresponding alkoxyacetic acids. Nasal tissue. Simply put, “glycol” is a term for any organic compound belonging to the alcohol family. Dipropylene glycol n-butyl ether (DPnB), CAS No. It is a colorless, nearly odorless liquid with a high boiling point and low toxicity. DIPROPYLENE GLYCOL Safety Data Sheet according to Federal Register / Vol. Oxybispropanol; Short-Term Toxicity. 29911-28-2 (35884-42-5) Dipropylene glycol methyl ether acetate (DPMA), CAS No 88917-22-0 Tripropylene glycol methyl ether (TPM), CAS No. Dipropylene glycol is a colorless, nearly odorless liquid with a high boiling point and lo… When a chemical is released from a large source, such as an industrial plant, or from a container, such as a drum or bottle, it enters the environment as a chemical emission. Uses Liver. (C88031B) Synonyms. Agent masquant; Solvant; Agent de contrôle de la viscosité ; Peut entrer dans la composition des parfums; Connaissances à ce jour. Dipropylene Glycol Monomethyl Ether (DPGME), CAS Reg. Its key attributes include low toxicity, chemical stability and high solubility. 77, No. Federal government websites often end in .gov or .mil. DIPROPYLENE GLYCOL METHYL ETHER may react violently with strong oxidizing agents. 34590-94-8. Not even close. 2 years (Dosed-Water)   Completed. May initiate the polymerization of isocyanates and epoxides. No. 13 weeks (Dosed-Water)  The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol monomethyl ether (EGM). Acute oral toxicity Dipropylene Glycol : LD50 Oral: > 5,000 mg/kg Species: rat Ingestion of high doses may cause discomfort and irritation of the gastrointestinal tract and CNS depression (fatigue, dizziness and possibly loss of concentration, with collapse,coma and death in cases of severe over-exposure). 58 / Monday, March 26, 2012 / Rules and Regulations Issue date: 07/05/2020 Revision date: 07/05/2020 Supersedes: 04/17/2015 07/05/2020 EN (English US) Page 1 SECTION 1: Identification 1.1. Dipropylene glycol - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information: Note: See Working with the Information on this Page section below for important notes about this data. Propylene glycol poisoning is marked initially by CNS depression and an elevated osmolal gap and, later, by an increased anion gap. Table 1. Micronucleus  Propylène Glycol et Glycérine végétale, voici tout ce qu’il faut savoir lorsqu’on tente de faire artisanalement son propre liquide ou quand on s’informe sur une fiole vendue en boutique. There are many different types of compounds that belong to this family, such as butylene glycol, polyethylene glycol, ethylene glycol, and more. It is completely soluble in water, and can also dissolve oils. The local toxic effects  Completed, Salmonella  This product is not intended for food use. Alibaba.com offers 117 dipropylene glycol toxicity products. Dipropylene glycol dimethyl ether, or DPDM, is a type of non-ionic solvent that is environmentally friendly and multifunctional. Dose: 0, 200, 800, 1500, 3000, OR 5000 MG/KG. > Propylene glycol, unlike ethylene glycol, does not cause kidney failure. Il est important de rappeler que pour ces études, ce sont des quantités très importantes de propylène glycol qui ont été administrées. In addition, dipropylene glycol is hygroscopic and acts as a humectant, which means it absorbs water and increases hydration in products. Dipropylene glycol is a mixture of three isomeric chemical compounds, 4-oxa-2,6-heptandiol, 2-(2-hydroxy-propoxy)-propan-1-ol, and 2-(2-hydroxy-1-methyl-ethoxy)-propan-1-ol. Dipropylene glycol is a mixture of three isomeric chemical compounds, 4-oxa-2,6-heptandiol, 2-(2-hydroxy-propoxy)-propan-1-ol, and 2-(2-hydroxy-1-methyl-ethoxy)-propan-1-ol. [2][3], Dipropylene glycol finds many uses as a plasticizer, an intermediate in industrial chemical reactions, as a polymerization initiator or monomer, and as a solvent. En conclusion, on pourra dire que le propylène glycol nest pas considéré à lheure actuelle comme une substance toxique, mais quil convient de le consommer avec modération. > Although both propylene glycol and ethylene glycol are chemically classified as glycols and both are metabolized, as a first step, by the same enzyme in the liver (alcohol dehydrogenase), ethylene glycol has a much high toxicity. Dipropylene glycol methyl ether Dipropylene glycol methyl ether (ACGIH:OSHA) Dowanol DPM Dowanol-50B Kino-red Methyl dipropanol Oxybispropanol methyl ether Ucar solvent 2LM. Chronic Toxicity and Carcinogenicity Did not cause cancer in laboratory animals. What is ethylene glycol? In animals, effects have been reported on the following organs after ingestion: Kidney. Propylene glycol has been identified in at least 5 of the 1,416 NPL sites. Repeated Dose Toxicity Dose levels producing these effects were many times higher than any dose levels expected from exposure due to use. Diethylene glycol dibenzoate will be essentially non-volatile from water surfaces(1,SRC) based on an estimated Henry's Law constant of 3X10-12 atm-cu m/mole(SRC), developed using a fragment constant estimation method(3). Is Dipropylene Glycol the same as Propylene Glycol? The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. The .gov means it's official. Dipropylene Glycol Methyl Ether Acetate Safety Data Sheet according to Federal Register / Vol. In cosmetics and personal care products, these ingredients are used in the formulation of hair and bath products, eye and facial makeup, fragrances, personal cleanliness products, and shaving and skin care products. (TRP90005) A wide variety of dipropylene glycol toxicity options are available to you, R: 0, 2, 500, 10, 000, or 10, 000 ppm; M: 0, 10, 000, 20, 000 or 40, 000 ppm; 50/SEX/DOSE. (TER90014) Skin and Eye Irritation and References.  Completed. This website and underlying databases are maintained and updated by Pesticide Action Network North America (PAN). Methyl- and ethyl-substituted ethylene glycol ethers can cause bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals. Dose: 0, 800, 1500, 3000, 5000, OR 8000 MG/KG. Standard toxicity studies conducted under good laboratory practices indicate a lack of genotoxic, developmental and reproductive hazards. Large doses and unusual circumstances are necessary for the development of propylene glycol toxicity. It belongs to the product categories of Organic matters.This chemical's molecular formula is C 6 H 14 O 3 and molecular weight is 134.17.Its EINECS number is 246-770-3. Endocrine disruption (low), Non-reproductive organ system toxicity (low), and Irritation (skin, eyes, or lungs) (moderate) fragrance ingredient, solvent, viscosity decreasing agent, masking, and viscosity controlling. (850639) It is a colorless, nearly odorless liquid with a high boiling point and low toxicity. and Dipropylene Glycol Butylene Glycol, Hexylene Glycol, Ethoxydiglycol, and Dipropylene Glycol are viscous liquids used in the cosmetic industry as humectants, emulsifiers, plasti- cizers, and solvents. The Dipropylene glycol, with the CAS registry number 25265-71-8, is also known as Oxydipropanol.  Completed. 30% distilled water: 35% dipropylene glycol: 35% triethylene glycol (long-lasting fog) 30% distilled water: 70% dipropylene glycol (dense fog) The resulting smoke should not smell "burnt." 2 … Plusieurs études par voies orale, cutanée ou sous-cutanée ont montré que le propylène-glycol n'est pas cancérogène chez le rat et la souris.  Completed, 6 to 19 GD Conventional Teratology (Gavage)  DPM caused no significant changes in the clinical chemistry, haematology, or pathology, whereas EGM caused … Dipropylene glycol is a member of the glycol class of compounds. National Institute of Environmental Health Sciences, Testing Status of Dipropylene glycol M88175, 2 weeks (Dosed-Water)  [1, 24] Le propylène-glycol n’agit ni sur la fertilité ni sur le déve loppement des animaux. CAMEO Chemicals. An official website of the United States government. Dipropylene glycol has been shown to be of low toxicity ( Whittington's Dictionary of Plastics ), but to be an active irritant of the skin and the eye area ( Cosmetic Database ). Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0 OR 8.0 % (10/S/S). In comparison, one person who developed symptoms of toxicity was receiving 213 grams of propylene glycol per day. This emission, which is also called a release, does not always lead to exposure. 203-821-4 / 246-770-3 Autres appellations Dipropylene glycol. No. Testing Status of Dipropylene glycol M88175 . (C88031) Propylene glycol toxicity is metabolized to compounds that are normal constituents of the citric acid cycle. (TER91013) It is also a common ingredient in commercial fog fluid, used in entertainment industry smoke and haze machines. A robust toxicity database exists for the propylene glycol ethers that provide strong product safety support. 110-98-5 / 25265-71-8 N° CE. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue:methylethyl08/26/2018 Revision date: 08/26/2018 Supersedes: 06/01/2015 08/26/2018 EN (English US) Page 1 SECTION 1: Identification 1.1.  Completed. About the Chemical. The results of acute, subchronic, and chronic oral toxicity studies using a variety of animal species indicate a low order of toxicity for the Glycols. It is also a common ingredient in commercial fog fluid, used in entertainment industry fog machines. Strong product Safety support dissolve oils la toxicité du propylène glycol, with the CAS number! [ 1 ] was receiving 213 grams of propylene glycol methyl ether Acetate ( PMA ) No... 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